Student Posters Repository

The nucleotide excision repair (NER) DNA repair pathway is responsible for drug resistance against gold standard DNA damaging chemotherapies such as platinum-based drugs. I will present the computer-aided drug design pipeline implemented at the Alberta DNA Repair Consortium (ALDRECON) to identify new drugs inhibitors for key NER proteins, to improve the efficacy of current chemotherapies. The pipeline is based on molecular dynamics simulations and large-scale virtual screening experiments, followed by in-house biological validations of the in-silico hits, and has been successfully applied to the discovery of a promising pre-clinical drug candidate for colorectal cancer treatment.